Demencia frontotemporal – variante conductual como diagnóstico diferencial de trastornos psiquiátricos primarios
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https://doi.org/10.20453/rnp.v84i3.4035Palabras clave:
Demencia frontotemporal, diagnóstico diferencial, trastornos mentalesResumen
La demencia frontotemporal (DFT) fue descrita por Arnold Pick hace más de un siglo. Se trata de un tipo de demencia en el que predominan múltiples manifestaciones clínicas de conducta y lenguaje. Un primer subtipo, denominado demencia frontotemporal variante conductual (DFTvc) es el más frecuente y, debido a sus variadas formas de presentación, puede ser confundido con cuadros psiquiátricos primarios como depresión, trastorno bipolar, trastorno obsesivo-compulsivo, psicosis de inicio tardío, trastornos de control de impulsos y otras patologías. En épocas recientes se ha desarrollado una importante y prometedora corriente de investigaciones clínicas, neurobiológicas y genéticas, que ofrecen fascinantes perspectivas acerca de este trastorno, el cual se constituye así, en un paradigma de las intrincadas relaciones entre neurología y psiquiatría. Esta revisión examina bibliografía reciente sobre la DFTvc, con énfasis en aspectos de su diagnóstico diferencial.
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Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J, et al. Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain. 2011; 134:2456– 2477. doi: 10.1093/cerebro/awr179
Liu MN, Lau C, Lin CP. Precision medicine for frontotemporal dementia. Front Psychiatry. 2019; 10: 75. doi: 10.3389/fpsyt.2019.0007
Hodges JR, Piguet O. Progress and challenges in frontotemporal dementia research: a 20-year review. J Alzheimers Dis. 2018; 62: 1467-1480. doi: 10.3233/ JAD-171087
Piguet O, Kumfor F. Frontotemporal dementias: main syndromes and underlying brain changes. Curr Opin Neurol. 2020; 33:215-221. doi: 10.1097/ WCO.0000000000000792
Ducharme S, Dols A, Laforce R, Devenney E, Kumfor F, Stock JVD, et al. Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders. Brain. 2020; 143:1632-1650. doi: 10.1093/cerebro/awaa018
Silverman HE, Goldman JS, Huey ED. Links between the C9orf72 repeat expansion and psychiatric symptoms. Curr Neurol Neurosci Rep. 2019; 19:93. doi: 10.1007/s11910-019-1017-9
Ducharme S, Pearl-Dowler L, Gossink F, McCarthy J, Lai J, Dickerson BD, et al. The Frontotemporal Dementia versus Primary Psychiatric Disorder (FTD versus PPD) Checklist: A bedside clinical tool to identify behavioral variant FTD in patients with late-onset behavioral changes. J Alzheimers Dis. 2019; 67: 113-124.
Devenney EM, Ahmed RM, Hodges JR. Frontotemporal dementia. Handb Clin Neurol. 2019; 167: 279-299.
Ducharme S, Price BH, Larvie M, Dougherty DD, Dickerson BC. Clinical approach to the differential diagnosis between behavioral variant Frontotemporal Dementia and primary psychiatric disorders. Am J Psychiatry; 2015; 172: 827-837.
Ducharme S, Dickerson BD. The neuropsychiatric examination of the young-onset dementias. Psychiatr Clin North Am. 2015; 38:249-264.
Burrell JR, Halliday GM, Kril JJ, Ittner LM, Götz J, Kiernan MC, et al. The frontotemporal dementia-motor neuron disease continuum. Lancet. 2016; 27;388(10047):919-931.
Fernández-Matarrubia M, Matías-Guiu JA, Moreno- Ramos T, Matías-Guiu J. Demencia frontotemporal variante conductual: biomarcadores, una aproximación a la enfermedad. Neurología.2015; 30:50-61.
Rascovsky K, Grossman M. Clinical diagnostic criteria and classification controversies in frontotemporal lobar degeneration. Int Rev Psychiatry. 2013; 25(2): 145–158.
Onyike CU, Shinagawa S, Ellajosyula R. Frontotemporal Dementia: A cross-cultural perspective. En: Ghetti B, Buratti E, Boeve B, Rademakers R. (Eds.) Frontotemporal Dementias. Emerging Milestones of the 21st Century. Nueva York: Springer International Publishing; 2021. p.141- 150.
World Health Organization. Dementia Fact Sheet. Ginebra: World Health Organization; 2021. (Citado el 14 de junio del 2021). Disponible en: https://www. who.int/news-room/fact-sheets/detail/dementia
Custodio N, Wheelock A, Thumala D, Slachevsky A. Dementia in Latin America: Epidemiological evidence and implications for public policy. Front Aging Neurosci. 2017; 9: 221.
Young JJ, Lavakumar M, Tampi D, Balachandran S, Tampi RR. Frontotemporal dementia: latest evidence and clinical implications. Ther Adv Psychopharmacol. 2018; 8: 33-48.
Knopman DS, Roberts RO. Estimating the number of persons with Frontotemporal Lobar Degeneration in the US Population. J Mol Neurosci. 2011; 45: 330–335.
Bang J, Spina S, Miller BL. Frontotemporal Dementia. Lancet. 2015; 386(10004): 1672–1682.
Mukadam N, Sommerlad A, Huntley J, Livingston G. Population attributable fractions for risk factors for dementia in low-income and middle-income countries: an analysis using cross-sectional survey data. Lancet Glob Health. 2019; 7: e596-e603.
Custodio N, Herrera-Perez E, Lira D, Montesinos R, Bendezú L. Prevalence of Frontotemporal dementia in community-based studies in Latin America: a systematic review. Dement Neuropsychol. 2013; 7: 27–32.
Scarioni M, Gami-Patel P, Timar Y, Seelaar H, van Swieten JC, Rozemuller AJ, et al. Frontotemporal Dementia: Correlations between psychiatric symptoms and pathology. Ann Neurol. 2020; 87: 950–961.
Miller B, Llibre-Guerra JJ. Frontotemporal Dementia. Handb Clin Neurol. 2019; 165:33-45.
Greaves CV, Rohrer JD. An update on genetic frontotemporal dementia. J Neurol. 2019; 266: 2075- 2086.
Lanata SC, Miller BL. The behavioural variant frontotemporal dementia (bvFTD) syndrome in psychiatry. J Neurol Neursurg Psychiatry. 2016; 87:501-511.
Younes K, Miller BL. Frontotemporal Dementia: Neuropathology, Genetics, Neuroimaging, and Treatments. Psychiatr Clin North Am. 2020; 43:331- 344.
Pan XD, Chen XC. Clinic, neuropathology and molecular genetics of frontotemporal dementia: a mini-review. Transl Neurodegener. 2013;2:8.
Olszewska DA, Lonergan R, Fallon EM, Lynch T. Genetics of Frontotemporal Dementia. Curr Neurol Neurosci Rep. 2016; 16:107.
Vismara M, Cirnigliaro G, Piccoli E, Giorgetti F, Molteni L, Cremaschi L, et al. Crossing borders between Frontotemporal Dementia and psychiatric disorders: an updated overview. J Alzheimers Dis. 2020; 75: 661-673.
Seeley WW. Behavioral Variant Frontotemporal Dementia. Continuum (Minneap Minn). 2019; 25:76- 100.
Galimberti D, Dell’Osso B, Altamura C, Scarpini E. Psychiatric symptoms in Frontotemporal Dementia: Epidemiology, phenotypes, and differential diagnosis. Biol Psychiatry. 15;78:684-692
Gossink FT, Vijverberg EG, Krudop W, Scheltens P, Stek ML, Pijnenburg YA, et al. Psychosis in behavioral variant frontotemporal dementia. Neuropsychiatr Dis Treat. 2017; 13:1099-1106.
Ferenczi EA, Erkkinen MG, Feany MB, Fogel BS, Dafner KR. New-onset delusions heralding an underlying neurodegenerative condition: a case report and review of the literature. J Clin Psychiatry. 2020; 81 (2) 19r13027.
Custodio N, Becerra-Becerra Y, Cruzado L, Castro- Suárez S, Montesinos R, Bardales Y, et al. Nivel de conocimientos sobre demencia frontotemporal en una muestra de médicos que evalúan regularmente a pacientes con demencia en Lima-Perú. Rev Chil Neuropsiquiat. 2018; 56: 77-88.
Owen PAW, Castle DJ. Late-Onset Schizophrenia. Epidemiology, Diagnosis, Management and Outcomes. Drugs & Aging, 1999; 15: 81-89.
Seo SW, Thibodeau M-P, Perry DC, Hua A, Sidhu M, Sible I, et al. Early vs late age at onset frontotemporal dementia and frontotemporal lobar degeneration. Neurology. 2018;90: e1047–56.
Custodio N, Montesinos R, Cruzado L, Alva-Diaz C, Failoc-Rojas V, Celis V, et al. Estudio comparativo de la capacidad denominativa y la memoria episódica de los pacientes con demencia degenerativa. Rev Colomb Psiquiatr. 2020. doi: 10.1016/j. rcp.2020.09.003Disponible en: https:// www.sciencedirect.com/science/article/abs/pii/ S0034745020300834
Leroy M, Bertoux M, Skrobala E, Mode E, Adnet- Bonte C, Le Ver I, et al. Characteristics and progression of patients with frontotemporal dementia in a regional memory clinic network. Alzheimer’s Res Ther.2021; 13:19.
Onyike CU. Psychiatric aspects of dementia. Continuum (Minneap Minn). 2016; 22(2): 600–614.
Devenney EM, Landin-Romero R, Irish M, Hornberger M, Mioshi E, Halliday GM, et al. The neural correlates and clinical characteristics of psychosis in the frontotemporal dementia continuum and the c9orf72 expansion. Neuroimage Clin. 2017; 13: 439–445.
Pressman PS, Matlock D, Ducharme S. Distinguishing Behavioral Variant Frontotemporal Dementia from primary psychiatric disorders: A review of recently published consensus recommendations from the Neuropsychiatric International Consortium for Frontotemporal Dementia. J Neuropsychiatry Clin Neurosci. 2021. Doi: 10.1176/appi.neuropsych.20090238
Bruno D, Slachevsky A, Fiorentino N, Rueda DS, Bruno G, Tagle AR, et al. Argentinian/Chilean validation of the Spanish-language version of Addenbrooke’s Cognitive Examination III for diagnosing dementia. Neurologia. 2020; 35:82-88.
Torralva T, Roca M, Gleichgerrcht E, Lopez P, Manes F. INECO Frontal Screening (IFS): a brief, sensitive, and specific tool to assess executive functions in dementia. J Int Neuropsychol Soc. 2009; 15: 777-786.
Bertoux M, Volle E, Funkiewiez A, De Souza LC, Leclercq D, Dubois B. Social cognition and emotional assessment (SEA) is a marker of medial and orbital frontal functions: A voxel-based morphometry study in behavioral variant of frontotemporal degeneration. J Int Neuropsychol Soc. 2012; 18: 972–985.
Milan G, Lamenza F, Iavarone A, Galeone F, Lorè E, De Falco C, et al. Frontal Behavioural Inventory in the differential diagnosis of dementia. Acta Neurol Scand. 2008; 117: 260–265.
Fernández AM, Dufey M, Kramp U. Testing the psychometric properties of the Interpersonal Reactivity Index (IRI) in Chile: Empathy in a different cultural context. Eur J Psychol Assess. 2011; 27: 179–185. 47. Paredes B, Stavraki M, Díaz D, Gandarillas B, Briñol P. Validity and Reliability of the Spanish Version of the Revised Self-Monitoring Scale. Span J Psychol. 2015;18: E71.
Custodio N, Duque L, Montesinos R, Alva-Diaz C, Mellado M, Slachevsky A. Systematic review of the diagnostic validity of Brief Cognitive Screenings for early dementia detection in Spanish-speaking adults in Latin America. Front Aging Neurosci. 2020; 12:270.
Torralva T, Bustin J, Dorman G, Roca M, Carrillo J, Marenc V, et al. Evaluación de las demencias. En Ibañez A, Slachevsky A, Serrano C (Eds). Manual de Buenas Prácticas para el diagnóstico de demencias. Buenos Aires, Argentina: Banco Interamericano de desarrollo; 2020. pp. 39-73.
Custodio N, Herrera-Pérez E, Montesinos R, Lira D, Metcalf T. Brief cognitive tests validated in Peru for detection of cognitive impairment: a systematic mapping of the scientific literature. Dement Neuropsychol. 2020; 14: 134-144.
Custodio N, Lira D, Montesinos R, Gleichgerrcht E, Manes F. Utilidad del Addenbrooke’s Cognitive Examination (versión en español) en pacientes peruanos con enfermedad de Alzheimer y demencia frontotemporal. Vertex. 2012; 23:165-172.
Henriquez F, Forno G, Olavarría L, Slachevsky A. Test de evaluación en demencia. En: Ibañez A, Slachevsky A, Serrano C (Eds). Manual de Buenas Prácticas para el diagnóstico de demencias. Buenos Aires: Banco Interamericano de desarrollo; 2020. pp. 75- 122.
Custodio N, Herrera-Perez E, Lira D, Roca M, Manes F, Báez S, et al. Evaluation of the INECO Frontal Screening and the Frontal Assessment Battery in Peruvian patients with Alzheimer’s disease and behavioral variant Frontotemporal dementia. eNeurologicalSci. 2016; 5: 25–29.
Ibañez A, Yokoyama JS, Possin KL, Matallana D, Lopera F, Nitrini R, et al. The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat): Driving Multicentric Research and Implementation Science. Front Neurol. 2021; 12: 631722.
Custodio N, Montesinos R, Cruzado L, Herrera- Perez E, Failoc-Rojas V, Pintado-Caipa M, et al. Social cognition and behavioral assessment improve the diagnosis of frontotemporal dementia in older Peruvians with low educational levels. Front Neurol. 2021. Doi: 10.3389/fneur.2021.704109
Peet BT, Castro-Suarez S, Miller BL. The Neuropsychiatric Features of Behavioral Variant Frontotemporal Dementia. En: Ghetti E, Buratti E, Boeve B, Rademakers R.; Editores. Frontotemporal Dementias. Emerging Milestones of the 21st Century. Nueva York: Springer International Publishing; 2021. pp.17-31.
Papazacharias A, Lozupone M, Barulli MR, Capozzo R, Imbimbo BP, Veneziani F, et al. Bipolar disorder and frontotemporal dementia; an intriguing association. J Alzheimers Dis. 2017; 55:973-979.
Mendez MF, Parand L, Akhlaghipour G. Bipolar disorder among patients diagnosed with frontotemporal dementia. J Neuropsychiatry Clin Neurosci. 2020; 32: 376-384.
Nascimento C, Villela-Nunes P, Diehl-Rodriguez R, Takada L, Suemoto CK, Tenenholz-Grinberg L, et al. A review on shared clinical and molecular mechanisms between bipolar disorder and frontotemporal dementia. Prog Neuropsychopharmacol Biol Psychiatry. 2019; 93:269-283.
Dols A, Krudop W, Möller C, Shulman K, Sajatovic M, Pijnenburg YAL. Late life bipolar disorder evolving into frontotemporal dementia. Neuropsychiatr Dis Treat. 2016; 12: 2207-2212.
Bersano E, Sarnelli MF, Solara V, De Marchi F, Sacchetti GM, Stecco A, et al. A case of late-onset OCD developing PLS and FTD. Amyotroph Lateral Scler Frontotemporal Degener. 2018; 19(5-6): 463- 465.
Pompanin S, Perini G, Toffanin T, Gnoato F, Cecchin D, Manara R, et al. Late-onset OCD as presenting manifestation of semantic dementia. Gen Hosp Psychiatry. 2012; 34: 102.e1-4.
Finney CM, Mendez MF. Diogenes syndrome in Frontotemporal dementia. Am J Alzheimers Dis Other Demen. 2017; 32:438-443.
Sacchi L, Rotondo E, Pozzoli S, Fiorentini A, Schinco G, Mandelli C, et al. Diogenes syndrome in dementia: a case report. BJPsych Open. 2021;7: e43.
Hall D, Finger EC. Psychotic symptoms in frontotemporal dementia. Curr Neurol Neurosci Rep. 2015; 15:46.
Shinagawa S, Nakajima S, Plitman E, Graff-Guerrero A, Mimura M, Nakayama K, Miller BL. Psychosis in Frontotemporal Dementia. J Alzheimers Dis. 2014;42:485-499.
Downey LE, Fletcher PD, Golden HI, Mahoney CJ, Agustus JL, Schott JM, et al. Altered body schema processing in frontotemporal demenctia with C9orf72 mutations. J Neurol Neurosurg Psychiatry. 2014; 85:1016-1023.
Smeyers J, Banchi E, Latouche M. C9ORF72: What It Is, What It Does, and Why It Matters. Front Cell Neurosci. 2021; 15:661447.
Solje E, Aaltokallio H, Koivumaa-Honkanen H, Suhonen NM, Moilanen V, Kiviharju A, et al. The phenotype of the C9ORF72 expansion carriers according to revised criteria for bvFTD. PLoS One. 2015;10: e0131817.
Saracino D, Le-Ber I. Clinical Update on C9orf72: Frontotemporal Dementia, Amyotrophic Lateral Sclerosis, and beyond. Adv Exp Med Biol. 2021; 1281:67-76.
Ducharme S, Bajestan S, Dickerson BC, Voon V. Psychiatric presentations of C9orf72 mutation: what are the diagnostic implication for clinicians? J Neuropsychiatry Clin Neurosci. 2017; 29:195-205.
Ducharme S, Dickerson BD, Larvie M, Price BH. Differentiating frontotemporal dementia from catatonia: a complex neuropsychiatric challenge. J Neuropsychiatry Clin Neurosci. 2015;27(2): e174- 176.
Sheikhi L, Li Y, Jimenez XF. A case of familial frontotemporal dementia presenting with malignant catatonia. Neurol Clin Pract. 2015; 5: 521–523.
Liljegren M, Naasan G, Temlett J, Perry DC, Rankin KP, Merrilees J, et al. Criminal behavior in frontotemporal dementia and Alzheimer disease. JAMA Neurol. 2015; 72: 295–300.
Shinagawa S, Shigenobu K, Tagai K, Fukuhara R, Kamimura N, Mori T, et al. Violation of Laws in Frontotemporal Dementia: A Multicenter Study in Japan. J Alzheimers Dis. 2017; 57: 1221–1227.
Birkhoff JM, Garberi C, Re L. The behavioral variant of frontotemporal dementia: an analysis of the literature and case report. Int J Law Psychiatry. 2016; 47:157-63.
Ahmed RM, Goldberg Z, Kaizik C, Kiernan MC, Hodges JR, Piguet O, et al. Neural correlates of changes in sexual function in frontotemporal dementia: implications for reward and physiological functioning. J Neurol. 2018; 265:2562-2572.
Manes FF, Torralva T, Roca M, Gleichgerrcht E, Bekinschtein A, Hodges JR. Frontotemporal dementia presenting as pathological gambling. Nat Rev Neurol. 2010; 6:347–352.
Tondo G, De Marchi F, Terazzi E, Sacchetti M, Cantello R. Frontotemporal dementia presenting as gambling disorder: When a Psychiatric condition is the clue to a neurodegenerative disease. Cogn Behav Neurol. 2017; 30:62–67.
Castro-Suarez S, Martinez P, Meza M. Ludopatía y epilepsia en demencia frontotemporal: reporte de dos casos. Rev Peru Med Exp Salud Publica. 2016; 33: 588-592.
Kalapatapu RK, Delucchi KL, Wang S, Harbison JD, Nelson EE, Kramer JH. Substance use history in behavioral-variant frontotemporal dementia versus primary progressive Aphasia. J Addict Dis. 2016; 35): 36–41.
Pose M, Cetkovich M, Gleichgerrcht E, Ibáñez A, Torralva T, Manes F. The overlap of symptomatic dimensions between frontotemporal dementia and several psychiatric disorders that appear in late adulthood. Int Rev Psychiatry. 2013; 25: 159–167.
Ahmed RM, Hodges JR, Piguet O. Behavioural Variant Frontotemporal Dementia: Recent Advances in the Diagnosis and Understanding of the Disorder. En: Ghetti E, Buratti E, Boeve B, Rademakers R.; Editores. Frontotemporal Dementias. Emerging Milestones of the 21st Century. Nueva York: Springer International Publishing; 2021. pp.17-31.
Korhonen T, Katisko K, Cajanus A, Hartikainen P, Koivisto AM, Haapasalo A, et al. Comparison of prodromal symptoms of patients with Behavioral Variant Frontotemporal Dementia and Alzheimer Disease. Dement Geriatr Cogn Disord. 2020; 49:98–106.
Brun A, Gustafson L. The birth and early evolution of the frontotemporal dementia (FTD) concept. J Mol Neurosci. 2011; 45:324-329.
Pérez-Romero A, González-Garrido S. La importancia de los síntomas psicológicos y conductuales (SPCD) en la enfermedad de Alzheimer. Neurología. 2018; 33:378-384.
González-Palau F, Buonanotte F, Cáceres MM. Del deterioro cognitivo leve al trastorno neurocognitivo menor: avances en torno al constructo. Neurologia argentina. 2015; 7: 51-58.
Taragano FE, Allegri RF, Lyketsos C. Mild behavioral impairment: A prodromal stage of dementia. Dement Neuropsychol. 2008; 2:256-260.
Taragano FE, Allegri RF, Krupitzki H, Sarasola DR, Serrano CM, Loñ L, et al. Mild behavioral impairment and risk of dementia: a prospective cohort study of 358 patients. J Clin Psychiatry. 2009; 70:584-92.
Ismail Z, Smith EE, Geda Y, Sultzer D, Brodaty H, Smith G, et al. Neuropsychiatric symptoms as early manifestations of emergent dementia: Provisional diagnostic criteria for mild behavioral impairment. Alzheimers Dement. 2016; 12:195-202.
Ismail Z, Agüera-Ortiz L, Brodaty H, Cieslak A, Cummings J, Fischer CE, et al. The Mild Behavioral Impairment Checklist (MBI-C): A rating scale for neuropsychiatric symptoms in pre-dementia populations. J Alzheimers Dis. 2017; 56: 929–938.
Agüera-Ortiz LF, López-Álvarez J, del Nido-Varo L, Soria García-Rosel E, Pérez-Martínez DA, Ismail Z. Deterioro comportamental leve como antecedente de la demencia: presentación de los criterios diagnósticos y de la versión española de la escala MBI-C para su valoración. Rev Neurol. 2017; 65: 327-334.
Mortby ME, Lyketsos CG, Geda YE, Ismail Z. Special Issue on mild behavioral impairment and non- cognitive prodromes to dementia Int Psychogeriatr. 2018; 30:167-169.
Johnson E, Kumfor F. Overcoming apathy in frontotemporal dementia: challenges and future directions. Curr Opin Behav Sci. 2018; 22:82–89.
Delgado H. Curso de Psiquiatría. 5ta. ed. Barcelona: Editorial Médica Científica; 1969.
Robert P, Lanctôt KL, Agüera-Ortiz L, Aalten P, Bremond F, Defrancesco M, et al. Is it time to revise the diagnostic criteria for apathy in brain disorders? The 2018 international consensus group. Eur Psychiatry. 2018; 54:71-76.
Malpetti M, Jones PS, Tsvetanov KA, Rittman T, van Swieten JC, Borroni B, et al. Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes. Alzheimers Dement. 2021; 17:969-983.
Tavares TP, Mitchell DG, Coleman KK, Coleman BL, Shoesmith CL, Butler CR, et al. Early symptoms in symptomatic and preclinical genetic frontotemporal lobar degeneration. J Neurol Neurosurg Psychiatry. 2020; 91: 975-984.
Cheran G, Silverman H, Manoochehri M, Goldman J, Lee S, Wu L, et al. Psychiatric symptoms in preclinical behavioural-variant frontotemporal dementia in MAPT mutation carriers. J Neurol Neurosurg Psychiatry. 2018; 89:449-455.
Parand L, Akhlaghipour G, Mendez M. Mood Disturbances as a Prodrome to Behavioral Variant Frontotemporal Dementia. Neurology. 2020; 94 (15 Supplement): 5128.
Sakamoto-Valente E, Caramelli P, Boson- Gambogi L, Mariano LI, Cerqueira-Guimaraes H, Teixeira AL, et al. Phenocopy síndrome of behavioral variant frontotemporal dementia: a systematic review. Alzheimer’s Research & Therapy. 2019; 11:30.
Power C, Lawlor BA. The Behavioral Variant Frontotemporal Dementia Phenocopy Syndrome: A Review. J Geriatr Psychiatry Neurol. 2021; 34:196- 208.
Kipps CM, Hodges JR, Hornberger M. Nonprogressive behavioural frontotemporal dementia: recent developments and clinical implications of the ‘bvFTD phenocopy syndrome’. Curr Opin Neurol. 2010; 23:628-632.
Katiusko K, Cajanus A, Korhonen T, Remes AM, Haapasalo A, Solje E. Prodromal and early bvFTD: evaluating clinical features and current biomarkers. Front Neurosci. 2019; 13: 658.
Barro C, Chitnis T, Weiner HL. Blood neurofilament light: a critical review of its application to neurologic disease. Ann Clin Transl Neurol. 2020; 7: 2508– 2523.
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