Recurrence of Renal Cell Carcinoma: Case Report

Authors

DOI:

https://doi.org/10.20453/rmh.v37i1.6463

Keywords:

renal cell carcinoma, recurrence, therapeutics

Abstract

Up to 40% of patients with Stage II-III renal carcinoma eventually suffer a recurrence despite radical nephrectomy (RN). We present the case of a 40-year-old male with a diagnosis of clear cell carcinoma, who underwent RN with regional lymphadenectomy. He was on follow-up for 3 years with no evidence of metastasis. He came for consultation 19 years later, referring to pain in the left hypochondrium. Abdominal multislice CT scan showed a tumor in the left renal fossa. On positron emission tomography (PET/CT), a retroperitoneal tumor with active disease was confirmed, so resection was performed. This case emphasizes the need for long-term rigorous follow-up.

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Author Biographies

Luis R. Zegarra-Montes, Clínica San Felipe. Lima, Perú. / Universidad Peruana Cayetano Heredia. Lima, Perú.

Urología general y oncológica en Clínica San Felipe

Profesor Emérito Universidad Peruana Cayetano Heredia

Mario E. Garrido Toribio, Hospital Nacional Guillermo Almenara Irigoyen. Lima, Perú.

Encargado - Unidad Oncológica de Hospital Guillermo Almenara Irigoyen

Jose L. Medina Holguín, Clínica San Felipe. Lima, Perú.

Urología general y oncológica en Clínica San Felipe

Andrea Valdez , Universidad Peruana de Ciencias Aplicadas. Lima, Perú.

Médico Cirujano de Universidad Peruana de Ciencias Aplicadas

Estefano M. Benites , Universidad Peruana de Ciencias Aplicadas. Lima, Perú.

Médico Cirujano de Universidad Peruana de Ciencias Aplicadas

Jorge J. Valdés-Gómez, Instituto Arias-Stella. Lima, Perú.

  

References

Urushibara M, Nagata M, Okumura T, et al. Bladder metastasis with additional metastases in multiple other organs 4 years after radical nephrectomy for clear cell renal cell carcinoma: a case report and review of the literature. J Med Case Reports. 2022;16:131. doi:10.1186/s13256-022-03368-w

Motzer RJ, Jonasch E, Agarwal N, et al. Kidney cancer, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2022;20(1):71-90. doi:10.6004/jnccn.2022.0001

Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-249. doi:10.3322/caac.21660

Ferlay J, Ervik M, Lam F, et al. Global Cancer Observatory: Cancer Today: South America [Internet]. International Agency for Research on Cancer; 2024. Disponible en: https://gco.iarc.who.int/media/globocan/factsheets/populations/931-south-america-fact-sheet.pdf

Ferlay J, Ervik M, Lam F, et al. Global Cancer Observatory: Cancer Today: Peru [Internet]. International Agency for Research on Cancer; 2024. Disponible en: https://gco.iarc.who.int/media/globocan/factsheets/populations/604-peru-fact-sheet.pdf

Chin AI, Lam JS, Figlin RA, et al. Surveillance strategies for renal cell carcinoma patients following nephrectomy. Rev Urol [Internet] 2006 [citado en febrero de 2025];8(1):1-7. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC1471767/

Dabestani S, Thorstenson A, Lindblad P, et al. Renal cell carcinoma recurrences and metastases in primary non-metastatic patients: a population-based study. World J Urol. 2016;34:1081-6. doi:10.1007/s00345-016-1773-y

Newmark JR, Newmark GM, Epstein JI, et al. Solitary late recurrence of renal cell carcinoma. Urology. 1994;43(5):725-8. doi:10.1016/0090-4295(94)90199-6

Romeo A, Garcia P, Jurado AM, et al. Renal fossa recurrence after radical nephrectomy: current management, and oncological outcomes. Urol Oncol. 2020;38(2):42.e7-12. doi:10.1016/j.urolonc.2019.10.004

Markinez I, Jiménez R, Ruiz I, et al. Metástasis pancreáticas por carcinoma renal. Nuestra casuística y revisión de la literatura. Cir Esp. 2013;91(2):90-5. doi:10.1016/j.ciresp.2012.07.007

Thomas AZ, Adibi M, Borregales LD, et al. Surgical management of local retroperitoneal recurrence of renal cell carcinoma after radical nephrectomy. J Urol. 2015;194(2):316-22. doi:10.1016/j.juro.2015.02.2943

Bruno JJ II, Snyder ME, Motzer RJ, et al. Renal cell carcinoma local recurrences: impact of surgical treatment and concomitant metastasis on survival. BJU Int. 2006;97(5):933-8. doi:10.1111/j.1464-410X.2006.06076.x

Marconi L, Kuusk T, Capitanio U, et al. Local treatment of recurrent renal cell carcinoma may have a significant survival effect across all risk-of-recurrence groups. Eur Urol Open Sci. 2023;47:65-72. doi:10.1016/j.euros.2022.11.008

Huang J, Wang Y, Zhang C, et al. Surgical management and oncologic outcomes for local retroperitoneal recurrence of renal cell carcinoma after radical nephrectomy. Clin Genitourin Cancer. 2023;21(2):315.e1-7. doi:10.1016/j.clgc.2022.10.010

Psutka SP, Heidenreich M, Boorjian SA, et al. Renal fossa recurrence after nephrectomy for renal cell carcinoma: prognostic features and oncological outcomes. BJU Int. 2016;119(1):116-27. doi:10.1111/bju.13620

Ljungberg B, Albiges L, Abu-Ghanem Y, et al. European Association of Urology guidelines on renal cell carcinoma: the 2022 update. Eur Urol. 2022;82(4):399-410. doi:10.1016/j.eururo.2022.03.006

Escudier B, Porta C, Schmidinger M, et al. Renal cell carcinoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2019;30(5):706-20. doi:10.1093/annonc/mdz056

Wei Y, Yuan J, Ren S, et al. Treatment of the recurrence after radical resection of clear cell renal cell carcinoma. Asian J Surg. 2023;46(2):1149-50. doi:10.1016/j.asjsur.2022.08.019

Itano NB, Blute ML, Spotts B, et al. Outcome of isolated renal cell carcinoma fossa recurrence after nephrectomy. J Urol. 2000;164(2):322-5. doi:10.1016/S0022-5347(05)67350-8

Sandhu SS, Symes A, A’Hern R, et al. Surgical excision of isolated renal-bed recurrence after radical nephrectomy for renal cell carcinoma. BJU Int. 2005;95(4):522-5. doi:10.1111/j.1464-410X.2005.05331.x

Master VA, Gottschalk AR, Kane C, et al. Management of isolated renal fossa recurrence following radical nephrectomy. J Urol. 2005;174(2):473-7. doi:10.1097/01.ju.0000165574.62188.d0

Johnson A, Sudarshan S, Liu J, et al. Feasibility and outcomes of repeat partial nephrectomy. J Urol. 2008;180(1):89-93. doi:10.1016/j.juro.2008.03.030

Published

2026-03-31

How to Cite

1.
Zegarra-Montes LR, Garrido Toribio ME, Medina Holguín JL, Valdez A, Benites EM, Valdés-Gómez JJ. Recurrence of Renal Cell Carcinoma: Case Report. Rev Méd Hered [Internet]. 2026 Mar. 31 [cited 2026 Apr. 7];37(1):34-9. Available from: https://revistas.upch.edu.pe/index.php/RMH/article/view/6463

Issue

Section

CASE REPORTS