Psiquiatría de precisión: una nueva frontera en la atención personalizada en salud mental

Segal A, Tiego J, Parkes L, Holmes AJ, Marquand AF, Fornito A. Embracing variability in the search for biological mechanisms of psychiatric illness. Trends Cogn Sci [Internet]. 2025; 29(1): 85-99. Disponible en: https://doi.org/10.1016/j.tics.2024.09.010

Kas MJ, Penninx BW, Knudsen GM, Cuthbert B, Falkai P, Sachs GS, et al. Precision psychiatry roadmap: towards a biology-informed framework for mental disorders. Mol Psychiatry [Internet]. 2025; 30(8): 3846-3855. Disponible en: https://doi.org/10.1038/s41380-025-03070-5

Miller AH, Berk M, Bloch G, Briquet-Laugier V, Brouillon C, Cuthbert BN, et al. Advancing precision psychiatry and targeted treatments: insights from immunopsychiatry. Brain Behav Immun [Internet]. 2025; 125: 319-329. Disponible en: https://doi.org/10.1016/j.bbi.2025.01.002

Rituraj, Pal RS, Wahlang J, Pal Y, Chaitanya M, Saxena S. Precision oncology: transforming cancer care through personalized medicine. Med Oncol [Internet]. 2025; 42(7): 246. Disponible en: https://doi.org/10.1007/s12032-025-02817-y

Comai S, Manchia M, Bosia M, Miola A, Poletti S, Benedetti F, et al. Moving toward precision and personalized treatment strategies in psychiatry. Int J Neuropsychopharmacol [Internet]. 2025; 28(5): pyaf025. Disponible en: https://doi.org/10.1093/ijnp/pyaf025

Coutts F, Koutsouleris N, McGuire P. Psychotic disorders as a framework for precision psychiatry. Nat Rev Neurol [Internet]. 2023; 19(4): 221-234. Disponible en: https://doi.org/10.1038/s41582-023-00779-1

Jones C, Nemeroff CB. Precision psychiatry: biomarker-guided tailored therapy for effective treatment and prevention in major depression [Internet]. In: Kim YK, editor. Major Depressive Disorder. Rethinking and Understanding Recent Discoveries. Singapore: Springer; 2021. pp. 535-563. Disponible en: https://doi.org/10.1007/978-981-33-6044-0_27

Kambeitz-Ilankovic L, Koutsouleris N, Upthegrove R. The potential of precision psychiatry: what is in reach? Br J Psychiatry [Internet]. 2022; 220(4): 175-178. Disponible en: https://doi.org/10.1192/bjp.2022.23

Williams LM, Carpenter WT, Carretta C, Papanastasiou E, Vaidyanathan U. Precision psychiatry and Research Domain Criteria: implications for clinical trials and future practice. CNS Spectr [Internet]. 2024; 29(1): 26-39. Disponible en: https://doi.org/10.1017/s1092852923002420

Del Casale A, Sarli G, Bargagna P, Polidori L, Alcibiade A, Zoppi T, et al. Machine learning and pharmacogenomics at the time of precision psychiatry. Curr Neuropharmacol [Internet]. 2023; 21(12): 2395-2408. Disponible en: https://doi.org/10.2174/1570159x21666230808170123

Conway CC, Kotov R, Krueger RF, Caspi A. Translating the hierarchical taxonomy of psychopathology (HiTOP) from potential to practice: ten research questions. Am Psychol [Internet]. 2023; 78(7): 873-885. Disponible en: https://doi.org/10.1037/amp0001046

Chin Fatt CR, Cooper CM, Jha MK, Minhajuddin A, Rush AJ, Trombello JM, et al. Differential response to SSRI versus Placebo and distinct neural signatures among data-driven subgroups of patients with major depressive disorder. J Affect Disord [Internet]. 2021; 282: 602-610. Disponible en: https://doi.org/10.1016/j.jad.2020.12.102

Murray GK, Lin T, Austin J, McGrath JJ, Hickie IB, Wray NR. Could polygenic risk scores be useful in psychiatry?: a review. JAMA Psychiatry [Internet]. 2021; 78(2): 210-219. Disponible en: https://doi.org/10.1001/jamapsychiatry.2020.3042

Wang X, Wei X, Shao J, Xue L, Chen Z, Yao Z, et al. Three latent factors in major depressive disorder base on functional connectivity show different treatment preferences. Hum Brain Mapp [Internet]. 2025; 46(8): e70215. Disponible en: https://doi.org/10.1002/hbm.70215

Miller AH. Advancing an inflammatory subtype of major depression. Am J Psychiatry [Internet]. 2025; 182(6): 516-524. Disponible en: https://doi.org/10.1176/appi.ajp.20250289

Lorvellec MA, Sipahimalani G, Lahutte B, Delacour H, Baldacci A, Saguin E. Pharmacogenetics testing for poor response to antidepressants: a transnosographic case series. Front Pharmacol [Internet]. 2024; 15: 1440523. Disponible en: https://doi.org/10.3389/fphar.2024.1440523

O'Driscoll C, Buckman JE, Fried EI, Saunders R, Cohen ZD, Ambler G, et al. The importance of transdiagnostic symptom level assessment to understanding prognosis for depressed adults: analysis of data from six randomised control trials. BMC Med [Internet]. 2021; 19: 109. Disponible en: https://doi.org/10.1186/s12916-021-01971-0

Harnas SJ, Knoop H, Sprangers MA, Braamse AM. Defining and operationalizing personalized psychological treatment - a systematic literature review. Cogn Behav Ther [Internet]. 2024; 53(5): 467-489. Disponible en: https://doi.org/10.1080/16506073.2024.2333345

Blasco D, Stortz SW, Grivel MM, Dishy GA, Samuel SS, Pilla D, et al. Naturalistic conceptions of genetic optimism and precision psychiatry among those at clinical high-risk for psychosis. Early Interv Psychiatry [Internet]. 2021; 15(3): 742-745. Disponible en: https://doi.org/10.1111/eip.12983

Fusar-Poli P, Manchia M, Koutsouleris N, Leslie D, Woopen C, Calkins ME, et al. Ethical considerations for precision psychiatry: a roadmap for research and clinical practice. Eur Neuropsychopharmacol [Internet]. 2022; 63: 17-34. Disponible en: https://doi.org/10.1016/j.euroneuro.2022.08.001