Vaccination in Pregnancy: Efficacy, Effectiveness, Safety, and Challenges for Maternal and Infant Health
DOI:
https://doi.org/10.20453/rmh.v37i1.7222Keywords:
immunization schedule, maternal-child health, communicable disease controlAbstract
Vaccination during pregnancy is essential to protect the mother and newborn against preventable infections and reduce complications such as preterm delivery, low birth weight, and mortality. In Peru, immunization against influenza, tetanus, diphtheria, pertussis, hepatitis B, COVID-19, and against respiratory syncytial virus (RSV) is being prioritized under evaluation. However, gaps in reporting on coverage in pregnant women and heterogeneity in implementation persist. Serious adverse events are infrequent and not associated with adverse obstetric or neonatal outcomes. Improvements in epidemiological surveillance, recording of coverage in pregnant women, equitable access and active recommendation in prenatal control are required.
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Hussain T, Murtaza G, Kalhoro DH, Kalhoro MS, Yin Y, Chughtai MI, et al. Understanding the Immune System in Fetal Protection and Maternal Infections during Pregnancy. J Immunol Res. 2022;2022:7567708. doi:10.1155/2022/7567708
Langel S, Blasi M, Permar S. Maternal immune protection against infectious diseases. Cell Host Microbe. 2022;30(5):660-74. doi:10.1016/j.chom.2022.04.007
Ministerio de Salud (PE). Tablero de información de inmunizaciones 2018-2024, Perú [Internet]. Lima: Minsa/REUNIS; 2022 [citado el 18 de septiembre de 2025]. Disponible en: https://www.minsa.gob.pe/reunis/data/Indicadores_Inmunizaciones.asp
Ciudad-Reynaud A, Mendoza W. La vacunación contra el COVID-19 en gestantes peruanas. Rev Peru Ginecol Obstet. 2022;68(1):1-4. doi:10.31403/rpgo.v68i2394
Ministerio de Salud (PE). Norma Técnica de Salud n.º 196-MINSA/DGIESP-2022, que establece el Esquema Nacional de Vacunación [Internet]. Lima: Ministerio de Salud (PE); 2022, 7 de noviembre. Disponible en: https://cdn.www.gob.pe/uploads/document/file/3823311/Norma%20Técnica%20de%20Salud.pdf
Ministerio de Salud (PE). Resolución Ministerial n.° 218-2024/MINSA, que modifica la NTS n.º 196-MINSA/DGIESP-2022 [Internet]. Lima: Ministerio de Salud (PE); 2024, 27 de marzo. Disponible en: https://cdn.www.gob.pe/uploads/document/file/6124416/5412702-resolucion-ministerial-n-218-2024-minsa.pdf
Ministerio de Salud (PE). Norma Técnica de Salud n.º 208-MINSA/DGIESP-2023, que establece la vacunación contra la COVID-19 [Internet]. Lima: Ministerio de Salud (PE); 2023, 9 de septiembre. Disponible en: https://cdn.www.gob.pe/uploads/document/file/5109510/Resolución%20Ministerial%20N°%20863-2023-MINSA.pdf
Ministerio de Salud (PE). Resolución Ministerial n.° 560-2024-MINSA, que modifica el subnumeral 6.5.4 del numeral 6.5 de la a NTS n.° 208-MINSA/DGIESP-2023 [Internet]. Lima: Ministerio de Salud (PE); 2024, 20 de agosto. Disponible en: https://cdn.www.gob.pe/uploads/document/file/6812684/5898172-resolucion-ministerial-n-560-2024-minsa.pdf
Ministerio de Salud y Protección Social (CO). Esquema de vacunación de Colombia [Internet]. Bogotá: MinSalud; 2019. Disponible en: https://web.archive.org/web/20201104181915/https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/PP/ET/ficha-esquema-vacunacion-vf2.pdf
Ministerio de Salud (AR). Calendario Nacional de Vacunación [Internet]. Buenos Aires: MSAL; 2025. Disponible en: https://www.argentina.gob.ar/sites/default/files/2025-01-v2-calendario-nacional-vacunacion.pdf
Ministerio de Salud (BO). Manual técnico: Programa ampliado de inmunización familiar y comunitaria [Internet]. La Paz: Ministerio de Salud; 2016. Disponible en: https://www.sedeslapaz.gob.bo/wp-content/uploads/2024/10/MANUAL-TECNICO-PROGRAMA-AMPLIADO-DE-INMUNICACION-FAMILIAR-Y-COMUNITARIA.pdf
Ministério da Saúde (BR). Calendário Nacional de Vacinação da Gestante [Internet]. Brasília: Ministério da Saúde; 2023. Disponible en: https://web.archive.org/web/20240926142235/https://www.gov.br/saude/pt-br/vacinacao/calendario-tecnico/calendario-tecnico-nacional-de-vacinacao-da-gestante
Ministerio de Salud (CL). Calendario de Inmunizaciones 2024 [Internet]. Santiago de Chile: Ministerio de Salud; 2024. Disponible en: https://web.archive.org/web/20241112102547/https://saludresponde.minsal.cl/wp-content/uploads/2024/05/CALENDARIOS-INMUNIZACIONES-2024-nonvalente.pdf
Ministerio de Salud Pública (EC). Lineamientos operativos: Campaña de influenza estacional, temporada 2024-2025 [Internet]. Quito: MSP; 2024. Disponible en: https://www.salud.gob.ec/wp-content/uploads/2024/11/Lineamiento_influenza_2024-2025.pdf
Ministerio de Salud Pública y Bienestar Social (PY). Normas nacionales de vacunación, técnico administrativas y de vigilancia del Programa Nacional de Enfermedades Inmunoprevenibles y PAI [Internet]. 3.a ed. Asunción: MSPBS; 2017. Disponible en: https://pai.mspbs.gov.py/wp-content/uploads/2023/03/NORMAS-NACIONALES-DE-VACUNACION-3ra-Edicion-2017.pdf
Ministerio de Salud Pública (UY). Esquema nacional de vacunación [Internet]. Montevideo: MSP; 2022 [citado el 27 de febrero de 2025]. Disponible en: https://www.gub.uy/ministerio-salud-publica/comunicacion/publicaciones/esquema-nacional-vacunacion
Organización Panamericana de la Salud. Semana de Vacunación en las Américas (SVA) 2024: Calendario de Vacunación – Vacúnate Bolivia [Internet]. OPS; 2024. Disponible en https://www.paho.org/sites/default/files/2024-03/paho-brochure-trifold-esp-bolivia-print2024.pdf
Ministerio de Salud y Protección Social (CO). Resolución n.º 00986 de 2023, por la cual se establecen los lineamientos para la aplicación de las vacunas contra la COVID-19 [Internet]. Bogotá: Ministerio de Salud y Protección Social (CO); 2023, 21 de junio. Disponible en: https://web.archive.org/web/20250615184610/https://www.minsalud.gov.co/Normatividad_Nuevo/Resoluci%C3%B3n%20No.%20986%20de%202023.pdf
Ministerio de Salud Pública (EC). Lineamientos para la vacunación a mujeres embarazadas y en período de lactancia [Internet]. Quito: MSP; 2021. Disponible en: https://www.salud.gob.ec/wp-content/uploads/2021/06/Lineamientos-gestantes_lactantes_15_06_2021_VFJR-signed-signed-signed.pdf
Ministerio de Salud (AR). Manual de Vacunación. Vacuna COMINARTY MONOVARIANTE Ómicron XBB.1.5 (Vacuna COVID-19 ARNm, Pfizer monovariante) [Internet]. Buenos Aires: MSAL; 2024. Disponible en: https://www.argentina.gob.ar/sites/default/files/2021/01/lineamiento_tecnico_pfizer_monovariante_692024.pdf
Ministério da Saúde (BR). Instrução Normativa do Calendário Nacional de Vacinação 2024 [Internet]. Brasília: Ministério da Saúde; 2023. Disponible en: https://www.gov.br/saude/pt-br/vacinacao/publicacoes/instrucao-normativa-calendario-nacional-de-vacinacao-2024.pdf
Ministerio de Salud (CL). Ficha informativa de vacuna. Vacuna COVID-19 Spikevax XBB.1.5 (vacuna SARS-CoV-2 ARNm andusomerán) [Internet]. Santiago de Chile: Ministerio de Salud; 2024. Disponible en: https://www.ispch.gob.cl/wp-content/uploads/2024/01/FIV-Moderna-Monovalente-V01-30012024A-1.pdf
Ministerio de Salud Pública (UY). Vacunación contra COVID-19: Campaña 2025. Comirnaty® SARS-CoV-2 OMICRON JN.1 [Internet]. Montevideo: MSP; 2025. Disponible en: https://www.gub.uy/ministerio-salud-publica/sites/ministerio-salud-publica/files/documentos/publicaciones/Lineamientos%20t%C3%A9cnicos%20JN%201%20-%20Enero%202025_0.pdf
Organización Panamericana de la Salud. Guía de campo sobre la inmunización materna y neonatal para Latinoamérica y el Caribe [Internet]. Washington DC: OPS; 2017. Disponible en: https://iris.paho.org/bitstream/handle/10665.2/34149/9789275319505-spa.pdf
Centers for Disease Control and Prevention. Recommended adult immunization schedule for ages 19 years or older [Internet]. Atlanta, Georgia, EE. UU.: CDC; 2025. Disponible en: https://www.cdc.gov/vaccines/hcp/imz-schedules/downloads/adult/adult-combined-schedule.pdf
Properzi S, Carestia R, Birettoni V, Calesso V, Marinelli B, Scapicchi E et al. Vaccination of pregnant women: an overview of European policies and strategies to promote it. Front Public Health. 2024;12:1455318. doi:10.3389/fpubh.2024.1455318
World Health Organization. Diphtheria vaccine: WHO position paper, August 2017 - Recommendations. Vaccine. 2018;36(2):199-201. doi:10.1016/j.vaccine.2017.08.024
Organización Mundial de la Salud. Tétanos [Internet]. OMS; 2024 [citado el 27 de febrero de 2025]. Disponible en: https://www.who.int/es/news-room/fact-sheets/detail/tetanus
Organización Mundial de la Salud. Agenda de inmunización 2030 (AI2030): una estrategia mundial para no dejar a nadie atrás [Internet]. OMS; 2020. Disponible en: https://www.who.int/docs/default-source/immunization/strategy/ia2030/ia2030-document---spanish.pdf
Black RE, Huber DH, Curlin GT. Reduction of neonatal tetanus by mass immunization of non-pregnant women: duration of protection provided by one or two doses of aluminium-adsorbed tetanus toxoid. Bull World Health Organ. 1980;58(6):927-30.
Newell KW, Duenas A, LeBlanc DR, Garces N. The use of toxoid for the prevention of tetanus neonatorum. Final report of a double-blind controlled field trial. Bull World Health Organ. 1966;35(6):863-71.
World Health Organization. Tetanus reported cases and incidence [Internet]. WHO; 2023 [citado el 27 de febrero de 2025]. Disponible en: https://immunizationdata.who.int/global/wiise-detail-page/tetanus-reported-cases-and-incidence?CODE=Global&DISEASE=NTETANUS&YEAR=
Silveira CM, Cáceres VM, Dutra MG, Lopes-Camelo J, Castilla EE. Safety of tetanus toxoid in pregnant women: a hospital-based case- control study of congenital anomalies. Bull World Health Organ. 1995;73(5):605-8.
Centers for Disease Control and Prevention. Whooping cough (Pertussis): Symptoms of whooping cough [Internet]. CDC; 2024 [citado el 27 de febrero de 2025]. Disponible en: https://www.cdc.gov/pertussis/signs-symptoms/index.html
Munoz FM, Bond NH, Maccato M, Pinell P, Hammill HA, Swamy GK, et al. Safety and immunogenicity of tetanus diphtheria and acellular pertussis (Tdap) immunization during pregnancy in mothers and infants: a randomized clinical trial. JAMA. 2014;311(17):1760-9. doi:10.1001/jama.2014.3633
Becker-Dreps S, Butler AM, McGrath LJ, Boggess KA, Weber DJ, Li D, et al. Effectiveness of prenatal tetanus, diphtheria, acellular pertussis vaccination in the prevention of infant pertussis in the U.S. Am J Prev Med. 2018;55(2):159-66. doi:10.1016/j.amepre.2018.04.013
Santana CP, Luhm KR, Shimakura SE. Impact of Tdap vaccine during pregnancy on the incidence of pertussis in children under one year in Brazil - A time series analysis. Vaccine. 2021;39(6):976-83. doi:10.1016/j.vaccine.2020.12.056
Fernandes EG, Sato AP, Vaz-de-Lima LR, Rodrigues M, Leite D, de Brito CA, et al. The effectiveness of maternal pertussis vaccination in protecting newborn infants in Brazil: a case-control study. Vaccine. 2019;37(36):5481-4. doi:10.1016/j.vaccine.2019.03.049
Vygen-Bonnet S, Hellenbrand W, Garbe E, von Kries R, Bogdan C, Heininger U, et al. Safety and effectiveness of acellular pertussis vaccination during pregnancy: a systematic review. BMC Infect Dis. 2020;20(1):136. doi:10.1186/s12879-020-4824-3
Nguyen HS, Vo NP, Chen SY, Tam KW. The optimal strategy for pertussis vaccination: a systematic review and meta-analysis of randomized control trials and real-world data. Am J Obstet Gynecol. 2022;226(1):52-67. doi:10.1016/j.ajog.2021.06.096
Vygen-Bonnet S, Hellenbrand W, Garbe E, von Kries R, Bogdan C, Heininger U, et al. Safety and effectiveness of acellular pertussis vaccination during pregnancy: a systematic review. BMC Infect Dis. 2020;20(1):136. doi:10.1186/s12879-020-4824-3
Tseng HF, Sy LS, Ackerson BK, Lee GS, Luo Y, Florea A, et al. Safety of tetanus, diphtheria, acellular pertussis (Tdap) vaccination during pregnancy. Vaccine. 2022;40(32):4503-12. doi:10.1016/j.vaccine.2022.06.009
Florea A, Sy LS, Ackerson BK, Qian L, Luo Y, Becerra-Culqui T, et al. Investigating tetanus, diphtheria, acellular pertussis vaccination during pregnancy and risk of congenital anomalies. Infect Dis Ther. 2023;12(2):411-23. doi:10.1007/s40121-022-00731-8
Centers for Disease Control and Prevention. Influenza (gripe): Personas con mayor riesgo de presentar complicaciones por la influenza [Internet]. CDC; 2024 [citado el 27 de febrero de 2025]. Disponible en: https://espanol.cdc.gov/flu/highrisk/index.htm
Centers for Disease Control and Prevention. Influenza (gripe): Cómo prevenir la influenza estacional [Internet]. CDC; 2024 [citado el 27 de febrero de 2025]. Disponible en: https://espanol.cdc.gov/flu/prevention/index.html
Centers for Disease Control and Prevention. Influenza (gripe): Signos y síntomas de influenza [Internet]. CDC; 2024 [citado el 27 de febrero de 2025]. Disponible en: https://espanol.cdc.gov/flu/signs-symptoms/index.html
Quach TH, Mallis NA, Cordero JF. Influenza vaccine efficacy and effectiveness in pregnant women: systematic review and meta-analysis. Matern Child Health J. 2020;24(2):229-40. doi:10.1007/s10995-019-02844-y
Lindsey BB, Armitage EP, Kampmann B, de Silva TI. The efficacy, effectiveness, and immunogenicity of influenza vaccines in Africa: a systematic review. Lancet Infect Dis. 2019;19(4):e110-9. doi:10.1016/S1473-3099(18)30490-0. Erratum in: Lancet Infect Dis. 2019;19(6):e187. doi:10.1016/s1473-3099(19)30208-7
Omer SB, Clark DR, Madhi SA, Tapia MD, Nunes MC, Cutland CL, et al. Efficacy, duration of protection, birth outcomes, and infant growth associated with influenza vaccination in pregnancy: a pooled analysis of three randomised controlled trials. Lancet Respir Med. 2020;8(6):597-608. doi:10.1016/S2213-2600(19)30479-5
Mohammed H, Roberts CT, Grzeskowiak LE, Giles LC, Dekker GA, Marshall HS. Safety and protective effects of maternal influenza vaccination on pregnancy and birth outcomes: A prospective cohort study. EClinical Medicine. 2020;26:100522. doi:10.1016/j.eclinm.2020.100522
Bansal A, Trieu MC, Mohn KG, Cox RJ. Safety, immunogenicity, efficacy and effectiveness of inactivated influenza vaccines in healthy pregnant women and children under 5 years: an evidence-based clinical review. Front Immunol. 2021;12:744774. doi:10.3389/fimmu.2021.744774
Centers for Disease Control and Prevention. COVID-19: Vacunación contra el COVID-19 para mujeres embarazadas o en período de lactancia [Internet]. CDC; 2024 [citado el 27 de febrero de 2025]. Disponible en: https://espanol.cdc.gov/covid/vaccines/pregnant-or-breastfeeding.html
Ciapponi A, Berrueta M, Argento FJ, Ballivian J, Bardach A, Brizuela ME, et al. Safety and effectiveness of COVID-19 vaccines during pregnancy: a living systematic review and meta-analysis. Drug Saf. 2024;47(10):991-1010. doi:10.1007/s40264-024-01458-w
Fernández-García S, Del Campo-Albendea L, Sambamoorthi D, Sheikh J, Lau K, Osei-Lah N, et al. Effectiveness and safety of COVID-19 vaccines on maternal and perinatal outcomes: a systematic review and meta-analysis. BMJ Glob Health. 2024;9(4):e014247. doi:10.1136/bmjgh-2023-014247
Wu S, Wang L, Dong J, Bao Y, Liu X, Li Y, et al. The dose- and time-dependent effectiveness and safety associated with COVID-19 vaccination during pregnancy: a systematic review and meta-analysis. Int J Infect Dis. 2023;128:335-46. doi:10.1016/j.ijid.2023.01.018
Ciapponi A, Berrueta M, Parker EP, Bardach A, Mazzoni A, Anderson SA, et al. Safety of COVID-19 vaccines during pregnancy: a systematic review and meta-analysis. Vaccine. 2023;41(25):3688-3700. doi:10.1016/j.vaccine.2023.03.038
Hagrass AI, Almadhoon HW, Al-Kafarna M, Almaghary BK, Nourelden AZ, Fathallah AH, et al. Maternal and neonatal safety outcomes after SAR-CoV-2 vaccination during pregnancy: a systematic review and meta-analysis. BMC Pregnancy Childbirth. 2022;22(1):581. doi:10.1186/s12884-022-04884-9
Zhang D, Huang T, Chen Z, Zhang L, Gao Q, Liu G, et al. Systematic review and meta-analysis of neonatal outcomes of COVID-19 vaccination in pregnancy. Pediatr Res. 2023;94(1):34-42. doi:10.1038/s41390-022-02421-0
Oliveira JA, da Silva EG, Karasu AF, Silva AM, Philip CE. Neonatal and maternal outcomes of mRNA versus Non-mRNA COVID-19 vaccines in pregnant patients: a systematic review and meta-analysis. Rev Bras Ginecol Obstet. 2024;46:e-rbgo69. doi:10.61622/rbgo/2024rbgo69
Gentile I, Borgia G. Vertical transmission of hepatitis B virus: challenges and solutions. Int J Womens Health. 2014;6:605-11. doi:10.2147/IJWH.S51138
Organización Panamericana de la Salud. Vacunas contra la hepatitis [Internet]. OPS; [s. f.] [citado el 27 de febrero de 2025]. Disponible en: https://www.paho.org/es/tag/vacunas-contra-hepatitis
Hou J, Liu Z, Gu F. Epidemiology and prevention of hepatitis B virus infection. Int J Med Sci. 2005;2(1):50-7. doi:10.7150/ijms.2.50
Sheffield JS, Hickman A, Tang J, Moss K, Kourosh A, Crawford NM, Wendel GD. Efficacy of an accelerated hepatitis B vaccination program during pregnancy. Obstet Gynecol. 2011;117(5):1130-5. doi:10.1097/AOG.0b013e3182148efe
Jin H, Tan Z, Zhang X, Wang B, Zhao Y, Liu P. Comparison of accelerated and standard hepatitis B vaccination schedules in high-risk healthy adults: a meta-analysis of randomized controlled trials. PLoS One. 2015;10(7):e0133464. doi:10.1371/journal.pone.0133464
Gupta I, Ratho RK. Immunogenicity and safety of two schedules of Hepatitis B vaccination during pregnancy. J Obstet Gynaecol Res. 2003;29(2):84-6. doi:10.1046/j.1341-8076.2002.00076.x
Male V, Jones CE. Vaccination in pregnancy to protect the newborn. Nat Rev Immunol. 2025;25(9):649-61. doi:10.1038/s41577-025-01162-5
Terrault NA, Lok AS, McMahon BJ, Chang KM, Hwang JP, Jonas MM, et al. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance. Hepatology. 2018;67(4):1560-99. doi:10.1002/hep.29800
Male V, Jones CE. Vaccination in pregnancy to protect the newborn. Nat Rev Immunol. 2025;25(9):649-61. doi:10.1038/s41577-025-01162-5
Celzo F, Buyse H, Welby S, Ibrahimi A. Safety evaluation of adverse events following vaccination with Havrix, Engerix-B or Twinrix during pregnancy. Vaccine. 2020;38(40):6215-23. doi:10.1016/j.vaccine.2020.07.041
Moro PL, Zheteyeva Y, Barash F, Lewis P, Cano M. Assessing the safety of hepatitis B vaccination during pregnancy in the Vaccine Adverse Event Reporting System (VAERS), 1990-2016. Vaccine. 2018;36(1):50-4. doi:10.1016/j.vaccine.2017.11.039
Groom HC, Irving SA, Koppolu P, Smith N, Vazquez-Benitez G, Kharbanda EO, et al. Uptake and safety of hepatitis B vaccination during pregnancy: a vaccine safety datalink study. Vaccine. 2018;36(41):6111-6. doi:10.1016/j.vaccine.2018.08.074
Centers for Disease Control and Prevention. Respiratory Syncytial Virus Infection (RSV): About RSV [Internet]. CDC; 2024 [citado el 27 de febrero de 2025]. Disponible en: https://www.cdc.gov/rsv/about/index.html
Li Y, Wang X, Blau DM, Caballero MT, Feikin DR, Gill CJ, et al. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis. Lancet. 2022;399(10340):2047-64. doi:10.1016/S0140-6736(22)00478-0
Centers for Disease Control and Prevention. Respiratory Syncytial Virus Infection (RSV): Immunizations to Protect Infants [Internet]. CDC; 2024 [citado el 27 de febrero de 2025]. Disponible en: https://www.cdc.gov/rsv/vaccines/protect-infants.html
Instituto Nacional de Salud (PE). Eficacia y seguridad de la vacuna contra el virus sincitial respiratorio en gestantes de 32 a 36 semanas de gestación [Internet]. Lima: Centro de Evaluación de Tecnologías en Salud; 2024. Serie de Revisiones Rápidas n.º 06-2024. Disponible en: https://cdn.www.gob.pe/uploads/document/file/6504008/5674347-revision-rapida-n-06_eficacia-y-seguridad-de-la-vacuna-contra-el-virus-sincitial-respiratorio-en-gestantes-de-32-a-36-semanas-de-gestacion%282%29.pdf
Simões EA, Pahud BA, Madhi SA, Kampmann B, Shittu E, Radley D, et al. Efficacy, safety, and immunogenicity of the MATISSE (Maternal Immunization Study for Safety and Efficacy) maternal respiratory syncytial virus prefusion F protein vaccine trial. Obstet Gynecol. 2025;145(2):157-67. doi:10.1097/AOG.0000000000005816
Razzini JL, Parada D, Solovey G, Guiñazú G, Sosa EM, Esposto S, et al. Impact and effectiveness of universal respiratory syncytial virus vaccination during pregnancy on infant hospitalizations in Buenos Aires: a retrospective cohort study. VeriXiv. 2025,2:34. doi;10.12688/verixiv.786.1
Pérez G, Vizzotti C, Fell DB, Di Nunzio L, Olszevicki S, Mankiewicz S, et al. Real-world effectiveness of RSVpreF vaccination during pregnancy against RSV-associated lower respiratory tract disease leading to hospitalisation in infants during the 2024 RSV season in Argentina (BERNI study): a multicentre, retrospective, test-negative, case–control study. Lancet Infect Dis. 2025;25(9):1044-54. doi:10.1016/S1473-3099(25)00156-2
Mapindra MP, Mahindra MP, McNamara P, Semple MG, Clark H, Madsen J. Respiratory syncytial virus maternal vaccination in infants below 6 months of age: meta-analysis of safety, immunogenicity, and efficacy. Neonatology. 2024;121(3):271-82. doi:10.1159/000536031
Madhi SA, Kampmann B, Simões EA, Zachariah P, Pahud BA, Radley D, et al. Preterm birth frequency and associated outcomes from the MATISSE (Maternal Immunization Study for Safety and Efficacy) maternal trial of the bivalent respiratory syncytial virus prefusion F protein vaccine. Obstet Gynecol. 2025;145(2):147-56. doi:10.1097/AOG.0000000000005817
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