The relevance of the 5HT2A–mGlu2 heterodimer in explaining the clinical ambivalence of psilocybin

Authors

  • Guillermo Escobar-Cornejo Universidad Católica de Santa María, Escuela Profesional de Psicología. Arequipa, Perú. https://orcid.org/0000-0001-5936-3023
  • Julián Corredor-Gamba Universidad de los Andes, Departamento de Psicología, Laboratorio de Neurociencia y Comportamiento. Bogotá, Colombia. https://orcid.org/0009-0005-6260-6432
  • Yoly Rodriguez-Rojas Universidad de los Andes, Departamento de Psicología, Laboratorio de Neurociencia y Comportamiento. Bogota, Colombia. https://orcid.org/0009-0009-9984-1777
  • F. P. Cárdenas Universidad de los Andes, Departamento de Psicología, Laboratorio de Neurociencia y Comportamiento. Bogota, Colombia. https://orcid.org/0000-0002-8826-6211

DOI:

https://doi.org/10.20453/rnp.v89i2.7539

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Author Biographies

Guillermo Escobar-Cornejo, Universidad Católica de Santa María, Escuela Profesional de Psicología. Arequipa, Perú.

      

Julián Corredor-Gamba, Universidad de los Andes, Departamento de Psicología, Laboratorio de Neurociencia y Comportamiento. Bogotá, Colombia.

I am a Master's student in Chemistry with research experience in neurobiology, psychopharmacology, and molecular neuroscience. My work focuses on neuroplasticity, neuroprotection, and the biochemical mechanisms underlying psychiatric disorders, using animal models, molecular biology techniques, and advanced imaging methods. I have also worked with in vitro models for cancer research, exploring biochemical and molecular mechanisms relevant to disease progression and treatment.

Yoly Rodriguez-Rojas, Universidad de los Andes, Departamento de Psicología, Laboratorio de Neurociencia y Comportamiento. Bogota, Colombia.

Biomedical Engineer pursuing a Master’s degree in Biomedical Engineering, with a strong interest in neuroscience and the development of innovative solutions to address neurodegenerative pathologies. Equipped with a solid foundation in biomedical principles, research methodologies, and cutting-edge technologies, I am driven to contribute to advancing the understanding and treatment of neurological disorders.

F. P. Cárdenas, Universidad de los Andes, Departamento de Psicología, Laboratorio de Neurociencia y Comportamiento. Bogota, Colombia.

Psychologist graduated from the National University of Colombia, MSc in Psychobiology and Ph.D. in Psychobiology (behavioral neuroscience). Doctor in Neuroscience and Behavior from the University of São Paulo in Ribeirão Preto. Associate Professor in the Department of Psychology at the University of the Andes, director of the Neuroscience and Behavior Laboratory. His area of research is neuroscience and behavioral psychopharmacology, with lines of work that include deep brain stimulation and emotional behavior and the study of animal models for Parkinson's disease and depression, among others.

References

Geiger HA, Wurst MG, Daniels RN. DARK classics in chemical neuroscience: psilocybin. ACS Chem Neurosci. 2018;9(10):2438–47. doi:10.1021/acschemneuro.8b00186

Compass. Compass Pathways Successfully Achieves Primary Endpoint in First Phase 3 Trial Evaluating COMP360 Psilocybin for Treatment-Resistant Depression [Internet]. Compass; 2025, June 23 [cited on September 8, 2025]. Available from: https://ir.compasspathways.com/News--Events-/news/news-details/2025/Compass-Pathways-Successfully-Achieves-Primary-Endpoint-in-First-Phase-3-Trial-Evaluating-COMP360-Psilocybin-for-Treatment-Resistant-Depression/default.aspx

Perna J, Trop J, Palitsky R, et al. Prolonged adverse effects from repeated psilocybin use in an underground psychedelic therapy training program: a case report. BMC Psychiatry. 2025;25(1):184. doi:10.1186/s12888-024-06303-z

Hatzipantelis CJ, Olson DE. The effects of psychedelics on neuronal physiology. Annu Rev Physiol. 2024;86:27–47. doi:10.1146/annurev-physiol-042022-020923

Ibi D. Role of interaction of mGlu2 and 5-HT2A receptors in antipsychotic effects. Pharmacol Biochem Behav. 2022;221:173474. doi:10.1016/j.pbb.2022.173474

Rieser NM, Gubser LP, Moujaes F, et al. Psilocybin-induced changes in cerebral blood flow are associated with acute and baseline inter-individual differences. Sci Rep. 2023;13:17475. doi:10.1038/s41598-023-44153-z

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Published

2026-06-30

How to Cite

1.
Escobar-Cornejo G, Corredor-Gamba J, Rodriguez-Rojas Y, Cárdenas FP. The relevance of the 5HT2A–mGlu2 heterodimer in explaining the clinical ambivalence of psilocybin. Rev Neuropsiquiatr [Internet]. 2026 Jun. 30 [cited 2026 Jul. 9];89(2):245-6. Available from: https://revistas.upch.edu.pe/index.php/RNP/article/view/7539

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