Symptomatic pain relief of postherpetic neuralgia with 5% lidocaine patch treatment: a case series report

Authors

  • Wendy Nieto-Gutierrez Universidad San Ignacio de Loyola, Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud. Lima, Perú.
  • Ian Falvy-Bockos Hospital Central de la Fuerza Aérea del Perú. Lima, Perú.
  • Claudia Becerra-Núñez Hospital Central de la Fuerza Aérea del Perú. Lima, Perú.
  • Yair E. Guzmán-Ramos Hospital Central de la Fuerza Aérea del Perú. Lima, Perú.
  • Enrique Orrillo-Leyva Asociación Peruana para el Estudio del Dolor (ASPED). Lima, Perú.
  • Carlos Vela Hospital Central de Aeronáutica, Unidad de Cuidados Paliativos. Lima, Perú.
  • Katia Ninoska Echegaray Castro Universidad Nacional Mayor de San Marcos. Lima, Perú.
  • Doris C. Reymer Clínica Internacional. Lima, Perú.
  • Jorge A. García-Mostajo Grünenthal Peruana. Lima, Perú.

DOI:

https://doi.org/10.20453/rnp.v87i3.5371

Keywords:

lidocaine, herpes zoster, neuralgia

Abstract

Objective: To describe the effects of the 5% lidocaine patch on the symptomatic relief of Peruvian patients with postherpetic neuralgia. Methods: Case series report of adult patients with post-herpetic neuralgia admitted to and treated at the Air Force Central Hospital in Lima. Symptomatic relief was defined as the difference between the specified pain score before and after patch treatment. The pain score was evaluated by the visual analogue scale and the Pain Assessment in Advanced Dementia scale, for patients with dementia. Results: Twenty-two patients with postherpetic neuralgia (mean age 74.4 ± 12.40 years) were recruited, 17 of whom began topical therapy with lidocaine following oral systemic treatment. The main reasons for the decision to change were a persistent pain and the adverse effects of the preceding therapy. A statistically significant decrease in pain symptoms was observed after the use of the lidocaine patch (p<0.01), and no adverse reactions to the patch were reported during the follow-up period. Conclusions: A statistically significant pain reduction found after the use of topical treatment. New studies that overcome the limitations of this and others previously published, are suggested.

Downloads

Download data is not yet available.

Author Biographies

Wendy Nieto-Gutierrez, Universidad San Ignacio de Loyola, Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud. Lima, Perú.

  

Ian Falvy-Bockos, Hospital Central de la Fuerza Aérea del Perú. Lima, Perú.

  

Claudia Becerra-Núñez, Hospital Central de la Fuerza Aérea del Perú. Lima, Perú.

  

Yair E. Guzmán-Ramos, Hospital Central de la Fuerza Aérea del Perú. Lima, Perú.

  

Enrique Orrillo-Leyva, Asociación Peruana para el Estudio del Dolor (ASPED). Lima, Perú.

  

Carlos Vela, Hospital Central de Aeronáutica, Unidad de Cuidados Paliativos. Lima, Perú.

  

Katia Ninoska Echegaray Castro, Universidad Nacional Mayor de San Marcos. Lima, Perú.

  

Doris C. Reymer, Clínica Internacional. Lima, Perú.

  

Jorge A. García-Mostajo, Grünenthal Peruana. Lima, Perú.

  

References

Gruver C, Guthmiller KB. Postherpetic neuralgia. In: StatPearls [Internet]. Treasure Island: StatPearls Publishing; 2024. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29630250/

Mick G, Baron R, Finnerup NB, Hans G, Kern KU, Brett B, et al. What is localized neuropathic pain? A first proposal to characterize and define a widely used term. Pain Manag [Internet]. 2012; 2(1): 71-77. Disponible en: https://doi.org/10.2217/pmt.11.77

Curran D, Schmidt-Ott R, Schutter U, Simon J, Anastassopoulou A, Matthews S. Impact of herpes zoster and postherpetic neuralgia on the quality of life of Germans aged 50 or above. BMC Infect Dis [Internet]. 2018; 18(1): 496. Disponible en: https://doi.org/10.1186/s12879-018-3395-z

Di Stefano G, Di Lionardo A, Di Pietro G, Cruccu G, Truini A. Pharmacotherapeutic options for managing neuropathic pain: a systematic review and meta-analysis. Pain Res Manag [Internet]. 2021; 2021(1): 6656863. Disponible en: https://doi.org/10.1155/2021/6656863

Shrestha M, Chen A. Modalities in managing postherpetic neuralgia. Korean J Pain [Internet]. 2018; 31(4): 235-243. Disponible en: https://doi.org/10.3344/kjp.2018.31.4.235

Krumova EK, Zeller M, Westermann A, Maier C. Lidocaine patch (5%) produces a selective, but incomplete block of Aδ and C fibers. Pain [Internet]. 2012; 153(2): 273-280. Disponible en: https://doi.org/10.1016/j.pain.2011.08.020

Buksnys T, Armstrong N, Worthy G, Sabatschus I, Boesl I, Buchheister B, et al. Systematic review and network meta-analysis of the efficacy and safety of lidocaine 700 mg medicated plaster vs. pregabalin. Curr Med Res Opin [Internet]. 2020; 36(1): 101-115. Disponible en: https://doi.org/10.1080/03007995.2019.1662687

Akhtar LN, Bowen CD, Renner DW, Pandey U, Della Fera AN, Kimberlin DW, et al. Genotypic and phenotypic diversity of herpes simplex virus 2 within the infected neonatal population. mSphere [Internet]. 2019; 4(1): e00590-18. Disponible en: https://doi.org/10.1128/msphere.00590-18

García-Soler Á, Sánchez-Iglesias I, Buiza C, Alaba J, Navarro AB, Arriola E, et al. Adaptación y validación de la versión española de la escala de evaluación de dolor en personas con demencia avanzada: PAINAD-Sp. Rev Esp Geriatr Gerontol [Internet]. 2014; 49(1): 10-14. Disponible en: https://doi.org/10.1016/j.regg.2013.02.001

Vicente-Herrero MT, Delgado-Bueno S, Bandrés-Moyá F, Ramírez-Iñiguez de la Torre MV, Capdevilla-García L. Valoración del dolor. Revisión comparativa de escalas y cuestionarios. Rev Soc Esp Dolor [Internet]. 2018; 25(4): 228-236. Disponible en: https://dx.doi.org/10.20986/resed.2018.3632/2017

Argoff CE. Review of current guidelines on the care of postherpetic neuralgia. Postgrad Med [Internet]. 2011; 123(5): 134-142. Disponible en: https://doi.org/10.3810/pgm.2011.09.2469

Hadi MA, McHugh GA, Closs SJ. Impact of chronic pain on patients’ quality of life: a comparative mixed-methods study. J Patient Exp [Internet]. 2019; 6(2): 133-141. Disponible en: https://doi.org/10.1177/2374373518786013

Pfizer Inc. Highlights of prescribing information. Pregabalin USA: Pfizer; 2020.

Sang CN, Sathyanarayana R, Sweeney M. Gastroretentive gabapentin (G-GR) formulation reduces intensity of pain associated with postherpetic neuralgia (PHN). Clin J Pain [Internet]. 2013; 29(4): 281-288. Disponible en: https://doi.org/10.1097/ajp.0b013e318258993e

Clère F, Delorme-Morin C, George B, Navez M, Rioult B, Tiberghien-Chatelain F, et al. 5% lidocaine medicated plaster in elderly patients with postherpetic neuralgia: results of a compassionate use programme in France. Drugs Aging [Internet]. 2011; 28(9): 693-702. Disponible en: https://doi.org/10.2165/11595600-000000000-00000

Baumann LS, Grunebaum L, Elsaie ML, Murdock J, Jablonka E, Figueras K, et al. Safety and efficacy of a rapid-acting topical 4% lidocaine gel in a unique drug delivery system. J Drugs Dermatol [Internet]. 2010; 9(12): 1500-1504. Disponible en: https://pubmed.ncbi.nlm.nih.gov/21120257/

Navez ML, Monella C, Bösl I, Sommer D, Delorme C. 5% lidocaine medicated plaster for the treatment of postherpetic neuralgia: a review of the clinical safety and tolerability. Pain Ther [Internet]. 2015; 4(1): 1-15. Disponible en: https://doi.org/10.1007/s40122-015-0034-x

Correa-Illanes G. Dolor neuropático, clasificación y estrategias de manejo para médicos generales. Rev Méd Clín Las Condes [Internet]. 2014; 25(2): 189-199. Disponible en: https://doi.org/10.1016/S0716-8640(14)70030-6

Sweeney J, Harms A. Persistent mechanical allodynia following injury of the hand. Treatment through mobilization of the nervous system. J Hand Ther [Internet]. 1996; 9(4): 328-338. Disponible en: https://doi.org/10.1016/s0894-1130(96)80038-x

Published

2024-09-30

How to Cite

1.
Nieto-Gutierrez W, Falvy-Bockos I, Becerra-Núñez C, Guzmán-Ramos YE, Orrillo-Leyva E, Vela C, et al. Symptomatic pain relief of postherpetic neuralgia with 5% lidocaine patch treatment: a case series report. Rev Neuropsiquiatr [Internet]. 2024 Sep. 30 [cited 2024 Oct. 28];87(3):239-46. Available from: https://revistas.upch.edu.pe/index.php/RNP/article/view/5371

Issue

Section

ORIGINAL ARTICLE