Association between altered proton magnetic resonance spectroscopy (1H MRS) findings and clinical symptoms of schizophrenia.

  • Senair Alberto Ambros School of Medicine, Universidade de Passo Fundo, Passo Fundo, Brazil. Department of Radiology, Hospital São Vicente de Paula, Passo Fundo, Brazil
  • Paulo Belmonte Abreu School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. Department of Psychiatry and Legal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
  • Eloísa Elena Ferreira Psychiatry Services, Hospital São Lucas da PUCRS, Porto Alegre, Brazil. Postgraduate Course in Neuroscience, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazi
  • Pdro Eugenio Ferreira
  • Luciana Estacia Ambros

Resumen

Objective: To assess the metabolic alterations of the thalamus in subjects with schizophrenia compared to healthy
subjects and to investigate whether specific schizophrenic symptoms are associated with metabolic alterations
measured by 1H MRS. Methods: This is a case-control study including patients with schizophrenia diagnosed using
the Diagnostic and Statistical Manual of Mental Disorders - Fourth Edition, DMS-IV and the Operational Criteria
Checklist for Psychotic Illness (OPCRIT). Proton magnetic resonance spectroscopy (1H MRS) was used to assess
metabolite concentrations (N-acetylaspartate, choline, creatinine, myoionositol and lactacte) in the left and right
thalamus of 13 patients with schizophrenia and 13 healthy controls. Results: In this study, concentrations of
specific metabolites in the thalamus, determined by 1H MRS, were similar for individuals with schizophrenia and
controls. It was observed that cases with family history of schizophrenia and disorganized speech demonstrated a
reduction in the ratio of the metabolites NAA /Cho in the thalamic nuclei on the right side. However, those with
organized delusions, hallucinations and non-affective auditory hallucinations had an increase of metabolites on the
right side compared to the left thalamus. Decreased thalamic metabolic activity in patients with positive symptoms
was observed in contrast with those who had well-organized delusions and auditory non-affective hallucinations,
core symptoms of schizophrenia. Conclusion: A lateralized thalamic involvement was verified, suggesting that
organic and genetic factors compromise the right thalamus and that the disorganization associated with delusions
and hallucinations compromises the left thalamic nuclei. Further studies to investigate the correlation between
symptoms and thalamic dysfunction are warranted. (Rev Neuropsiquiatr 2011;74:183-190)
Publicado
2013-02-22
Cómo citar
1.
Ambros S, Abreu P, Ferreira E, Ferreira P, Ambros L. Association between altered proton magnetic resonance spectroscopy (1H MRS) findings and clinical symptoms of schizophrenia. Revista de Neuro-Psiquiatria [Internet]. 22feb.2013 [citado 27jun.2022];74(1):183-90. Available from: https://revistas.upch.edu.pe/index.php/RNP/article/view/1672
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