Neuropsychiatric damage in Systemic Lupus Erythematosus: Possible protective role of medications.

Autores/as

  • Luis A. Gonzáles-Naranjo
  • Paula I. Burgos
  • Jie Zhang
  • Graciela S. Alarcón

DOI:

https://doi.org/10.20453/rnp.v71i1-4.1630

Resumen

Objective: To examine the possible role of medications in the occurrence of neuropsychiatric damage in patientswith systemic lupus erythematosus (SLE). Material and methods: SLE patients from the LUMINA (Lupus inMinorities: Nature vs. Nurture) cohort (ACR criteria, ≥ 16 years of age at enrollment and ≤5 years of diseaseduration) were studied. Time-to-neuropsychiatric damage [defined according with the Systemic Lupus CollaboratingClinics (SLICC) Damage Index (SDI): neurocognitive impairment or psychosis, seizures, cranial or peripheralneuropathy, stroke or surgical resection not due to malignancies and transverse myelitis] was examined by univariableand multivariable Cox regression analyses. Propensity score analyses were done to further determine the possibleprotective role of hydroxychloroquine in neuropsychiatric damage occurrence. Results: Six-hundred and thirtytwopatients were studied. Age, Caucasian ethnicity, disease activity over time, diabetes and abnormal illness-relatedbehaviors were associated with a shorter time-to-the occurrence of neuropsychiatric damage whereas photosensitivity,anemia, Raynaud’s phenomenon, hydroxychloroquine and a medium dose of prednisone were associated with alonger time. Although the direction of the association remained the same by propensity score analyses(hydroxychloroquine), significance was no longer evident. Conclusions: Our data suggest a possible protectiverole of hydroxychloroquine and moderate doses of prednisone in the occurrence of neuropsychiatric damage inpatients with SLE. (Rev. Neuropsiquiatría 2008; 71: 51-57).

Descargas

Los datos de descargas todavía no están disponibles.

Descargas

Publicado

2013-02-25

Cómo citar

1.
Gonzáles-Naranjo LA, Burgos PI, Zhang J, Alarcón GS. Neuropsychiatric damage in Systemic Lupus Erythematosus: Possible protective role of medications. Rev Neuropsiquiatr [Internet]. 25 de febrero de 2013 [citado 30 de octubre de 2024];71(1-4):51-7. Disponible en: https://revistas.upch.edu.pe/index.php/RNP/article/view/1630

Número

Sección

ARTÍCULO ORIGINAL