Increase in succinate dehydrogenase activity in mice brain during chronic hypoxia

Authors

  • R. Cáceda Universidad Peruana Cayetano Heredia, Departamento de Ciencias Fisiológicas, Laboratorio de Transporte de Oxígeno. Lima, Perú
  • J. Boero Universidad Peruana Cayetano Heredia, Facultad de Medicina, Laboratorio de Neurociencias. Lima, Perú
  • A. Arregui Universidad Peruana Cayetano Heredia, Facultad de Medicina, Laboratorio de Neurociencias. Lima, Perú

Keywords:

brain metabolism, succinate dehydrogenase, Hypoxia, mice

Abstract

Succinate dehydrogenase (SDH) activity was measured in seven brain regions of mice exposed to three weeks of hypobaric hypoxia (450 torr, 4380 meters above sea level) and compared to to normoxic sea level controls. In the hypoxic group we found an increased activity of SDH in cortex an hippocampus of 40%. These results can be explained as a compensatory mechanism for the decreased activity of other components of the respiratory chain in hypobaric hypoxia, as an strategy to mantain the normal ATP production. 

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Published

2025-08-11

How to Cite

Cáceda, R., Boero, J., & Arregui, A. (2025). Increase in succinate dehydrogenase activity in mice brain during chronic hypoxia. Acta Andina, 6(2), 142–144. Retrieved from https://revistas.upch.edu.pe/index.php/AA/article/view/6840

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Section

ARTICULOS