Estudio de pulmones de ratas con administracion de extracto de coca y drogas estimulantes de la respiracion

Abstract

A study was done in hipersensibilidad of Sprague Dawley rats that were administered an extract of coca leaves with dimethyl sulfoxide (DMSO) as solvent, pure DMSO, almitrine and as control, oophorectomized rats. The lungs of the rats with extract of coca leaves and DMSO exhibit acute intralveolar hemorrhage as a predominant finding while those of rats with pure DMSO and almitrine had more intersticial mononuclear infiltrate that suggests, according to other studies, a hypersensitivity reaction. In the group of oophorectomized rats all of these findings were scarse and mild. A universal finding in the lungs of these rats were a thinckened arteriolar wall that seems to be a reactive to high altitude hypoxia as seen in other rodents in the same envinronment.