Las hemoglobinopatías y la exposición aguda a la altura

Abstract

Hemoglobinophaties are congenital clinical conditions, in which due to genetic mutations results in biochemical alterations of chains of globin (or its balance). The condition affected by hypoxia is that related to hemoglobin S (Hb S). Hypoxia favours deformation of red blood cells forming the siclinkg. The magnitude of deoxigenation which is required to produce sickling varies according to the percentage of Hb S present in the red blood cell. In soccer teams there are black players or mestizo with black predominance. It is probably to find players with sick trait. The prevalence of sickle trait was determined in a sample of 15 soccer players of the Peruvian Soccer Selection, of whom five are black, five are white and five are mestizo (cobrizo to moreno). One of the players showed sickling of red blood cells in the test with sodium metabisulphide. This is confirmed by electrophoresis in which is observed the presence of hemoglobin S. The diagnosis is sickle trait. The prevalence was 6.7% with respect to all players, and 20% if it is related to black players, and 10% if white players are excluded from the analysis. The player with sickle trait had an hemoglobin concentration of 14.6 g/dl discarding anemia.