Niveles séricos maternos y neonatales de insulina y factores de crecimiento insulino-similes I y II (IGF y II) en la altura y a nivel mar.

Abstract

The present study was designed to determine serum levels of IGF-I, IGF-II and insulin in pregnant women during labour of parturition, and in newborns from sea level and from high altitudes (3700 m). For such purpose, subjects. were paired by age, parity, weight and height. They were studied during labour of parturition. IGF-I and IGF-II were measured by inmunoradiometric assay (IRMA) and insulin by radioinmunoassay (RIA) in maternal serum and blood from umbilical cord. In relation to women at sea level, serum levels of IGF-1 and insulin at high altitude were lower, 78.3 plus/minus 45.3 * v 455.2 plus/minus 499.1 ng/ml I(p = 0.029) and 11.3 plus/minus 7 U / m * l(p = 0.045) . respectively. No difference vs * 22.9 plus/minus 15.1 Il levels were observed. Placental weight/newborn weight ratio was higher at high altitude than at sea level, 7.18 plus/minus 0.03 vs 3.15 plus/minus 0.025 (p = 0.026) . Umbilical cord serum levels of IGF-1, IGF-11 and insulin were similar at sea level and at high altitude. IGF-1 correlated with weight of newborn at both places; sea level (SL) * r = 0.87 ( p = 0.1 ), altitude: r=0.97 (p=0.0001), and insulin correlated with newborn weight at SL, r=0.82 (p = 0.024) , but not at high altitude, t = 0.6 (p = 0.065) ; probably due to the small sample size. It is concluded that low birth weight at high altitude may be due to low levels of IGF-I and insulin. do IGF-1 e insulina.

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